Endocrine Abstracts

Aim: Bone turnover markers (BTMs) predict more rapid rates of bone loss. However, most of these studies have been carried out in postmenopausal women. Few prospective studies have examined the degradation marker C-terminal telopeptide of type I collagen (CTX) and the bone formation marker N-aminoterminal propeptide of type I collagen (P1NP) measured during the menopausal transition to predict the subsequent bone loss.Methods: We performed a prospective c...

Germinal mutations of the oncogene RET originate the development of medullary thyroid carcinoma (MTC) in carriers with phenotypic expression depending on the mutated codon and other unknown factors. Simultaneous detection of differentiated thyroid carcinomas is considered a casual phenomenon (collision tumours). We communicate two brothers with double heterozygous mutation of maternal inheritance at codon 611 of RET, TGC to TTT, changing to encode phenylalanine (C611F), with a...

Introduction: Patients referred for adrenal incidentalomas (AI) are increasing. Current guidelines are controversial on diagnosis and length of follow-up.Objectives: Analyze clinical, radiologic and hormonal characteristics of patients with AI. Evaluate the number and usefulness of tests needed for diagnosis, clinical outcome and follow up.Material and methods: Observational, retrospective study in patients with AI in our endocrino...

Background: There is a clear relationship between obesity and carbohydrate metabolism alterations (CMA), such as impaired glucose tolerance (IGT) and T2D. OGTT is used for the diagnosis of those alterations, but is not performed in case of normal fasting glucose values (NFG). Moreover, BMI underestimates the diagnosis of obesity and body composition alteration can be crucial to the development of abnormal carbohydrate metabolism. This study aimed to examine the discriminating ...

Introduction: Adrenal incidentalomas (AIs) are found in ~3% abdominal scans, rising to 10% in the elderly. In 2016, the European Society of Endocrinology (ESE) published new guidance on their management.Aims & objectives: To (1) compare how AIs have been managed at the University Hospital of Wales (UHW) against ESE guidelines, and (2) provide an early evaluation of the impact of service changes implemented based on initial findings.<p class="abst...

Activation of complement factor 5 (C5) produces the anaphylatoxin C5a and the proinflammatory cytolytic complex C5b-9. Recent studies have shown that C5a receptor (C5aR) deficiency leads to improved systemic and white adipose tissue (WAT) insulin sensitivity. This phenotype is considered to be due to the potent inflammatory potential of signalling through C5aR; however, the pleiotropic functions of C5 in inflammation and metabolism remain to be elucidated. We investigated the ...

Background: Acromegaly most commonly results from an excess production of GH and secondary increase in IGF1. More than 95% of the time from the pituitary gland, but the source of excess GH secretion may not necessarily be pituitary in origin. Ectopic acromegaly may arise due to neuroendocrine tumors by production of GHRH and in <0.5% of the cases from ectopic pituitary remnants in the sphenoid sinus.Clinical case: We present a case of a 37 years old ...

Obstructive sleep apnoea (OSA) is very common in severe obese patients and has been related to insulin resistance (IR) and hyperleptinemia, and these findings may have effects on food behavior and obesity complications. In order to explore this relationship and the role of sex we have studied 531 patients with morbid obesity (BMI 42.8+6.5 kg/m2). A full polysomnographic study and glucose, insulin and leptin measurements as well as air displacement plethysmography we...

Introduction: Isolated ACTH deficiency (IAD) is a rare entity characterized by secondary adrenal insufficiency with low levels of serum cortisol, decreased production of ACTH, adequate secretion of other pituitary hormones and normal pituitary structure on radioimaging. Due to the rarity of its occurrence the prevalence of IAD as a cause of secondary adrenal insufficiency has not been determined. To our knowledge 200 cases are described in the literature. Impairment of GH secr...

Hyperfunctional nodules of the thyroid are rarely associated with thyroid cancer, for these reason are rarely biopsied. Although multiple theories have being proposed, the relationship is still uncertain. After performing a MEDLINE literature search, we found in multiple retrospectives analysis, that patients with hyperthyroidism with hyperfunctional nodules have an estimated of 0.3–16.3% prevalence of malignancy. In our study forty-eight hyperthyroid cases were prospecti...